Nature Cell Biology contents: June 2018 Volume 20 Number 6

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Advertisement Do you have a career question?  The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud. Listen today! TABLE OF CONTENTS June 2018 Volume 20, Issue 6 Editorial Research Highlights News & Views Comment Letters Articles Resources   Advertisement Nature Index 2018 Japan Some of Japan's smallest institutions are among the most efficient in the production of high quality scientific research, though the decline in Japan's high quality scientific research output continues. This supplement examines reform efforts in light of the country's aim to become a "super-smart" society. Read the full supplement   Editorial   An update on organoid research    p633 doi:10.1038/s41556-018-0119-y Research Highlights   A biobank for bladder cancer    p634 Christine Weber doi:10.1038/s41556-018-0114-3 Modelling PDAC-niche adaption    p634 Christine Weber doi:10.1038/s41556-018-0115-2 Organoids test drug response    p634 Christine Weber doi:10.1038/s41556-018-0116-1 Gene corrections in sight    p634 Christine Weber doi:10.1038/s41556-018-0117-0 Nature Cell Biology JOBS of the week Postdoctoral Position University of Houston - College of Pharmacy Postdoctoral Scholar in Cardiovascular Medicine, UCLA UCLA Post Doctoral Research Fellow Health Sciences North Research Institute Research Specialist II Princeton University Post Doctoral Associate Weill Cornell Medicine More Science jobs from Nature Cell Biology EVENT Physical Biology of the Cell 29.07.18 Woods Hole, USA More science events from Advertisement Innovations In: The Biggest Questions in Science Read our new special report on the nature of spacetime, the origin of life, the source of consciousness, and other fundamental questions in science.  Access free online  Produced with support from: The Kavli Prize      News & Views   Protein quality and miRNA slicing get into phase    pp635 - 637 Tanja Mittag & Nicolas L. Fawzi doi:10.1038/s41556-018-0113-4 Mammary lineage restriction in development    pp637 - 639 Philip Bland & Beatrice A. Howard doi:10.1038/s41556-018-0111-6 A confetti trail of tumour evolution    pp639 - 641 Michalina Janiszewska & Kornelia Polyak doi:10.1038/s41556-018-0110-7 Comment   Consent for governance in the ethical use of organoids    pp642 - 645 Sarah N. Boers & Annelien L. Bredenoord doi:10.1038/s41556-018-0112-5 Letters   Regulation of cell cycle progression by cell–cell and cell–matrix forces    pp646 - 654 Marina Uroz, Sabrina Wistorf, Xavier Serra-Picamal, Vito Conte, Marta Sales-Pardo et al. doi:10.1038/s41556-018-0107-2 Monitoring growing epithelial cells through the cell cycle, Uroz et al. find that cell–cell tension and cell–matrix traction forces differ across the cell cycle and affect cell cycle duration, the G1–S transition and mitotic rounding.   Articles   A PAX5–OCT4–PRDM1 developmental switch specifies human primordial germ cells    pp655 - 665 Fang Fang, Benjamin Angulo, Ninuo Xia, Meena Sukhwani, Zhengyuan Wang et al. doi:10.1038/s41556-018-0094-3 Fang et al. identify a PAX5–OCT4–PRDM1 transcriptional network that acts as a developmental switch in the transition from human pluripotent stem cells to the primordial germ cell lineage.   Early lineage segregation of multipotent embryonic mammary gland progenitors    pp666 - 676 Aline Wuidart, Alejandro Sifrim, Marco Fioramonti, Shigeru Matsumura, Audrey Brisebarre et al. doi:10.1038/s41556-018-0095-2 Wuidart et al. show that the mammary gland develops from embryonic multipotent progenitors that switch from multipotency to unipotency and express a unique gene signature. ΔNp63 promotes their basal fate and also reprograms adult luminal cells.   Clonal analysis of Notch1-expressing cells reveals the existence of unipotent stem cells that retain long-term plasticity in the embryonic mammary gland    pp677 - 687 Anna M. Lilja, Veronica Rodilla, Mathilde Huyghe, Edouard Hannezo, Camille Landragin et al. doi:10.1038/s41556-018-0108-1 Lilja et al. report that multipotent mouse embryonic mammary cells become lineage restricted as early as embryonic day 12.5 during development in a potency switch regulated by Notch1 signalling.   Spectrin is a mechanoresponsive protein shaping fusogenic synapse architecture during myoblast fusion    pp688 - 698 Rui Duan, Ji Hoon Kim, Khurts Shilagardi, Eric S. Schiffhauer, Donghoon M. Lee et al. doi:10.1038/s41556-018-0106-3 Duan et al. find that the membrane skeleton protein spectrin is required for myoblast fusion in Drosophila, accumulating in a mechanosensitive manner in the receiving partner during cell–cell fusion to modulate adhesion and protrusion events.   Multicolour lineage tracing reveals clonal dynamics of squamous carcinoma evolution from initiation to metastasis    pp699 - 709 doi:10.1038/s41556-018-0109-0 Reeves et al. use a multistage skin carcinogenesis mouse model and multicoloured lineage tracing to analyse the different patterns of clonal evolution and behaviour seen in progressing and non-progressing papillomas.   Resources   Single-cell analysis identifies a CD33+ subset of human cord blood cells with high regenerative potential    pp710 - 720 David J. H. F. Knapp, Colin A. Hammond, Tony Hui, Marijn T. J. van Loenhout, Fangwu Wang et al. doi:10.1038/s41556-018-0104-5 Knapp et al. analyse the heterogeneous molecular profiles and functions of CD49f human cord blood haematopoietic stem cells and report that a subset with CD33 expression has improved regenerative activity.   Tracing the temporal-spatial transcriptome landscapes of the human fetal digestive tract using single-cell RNA-sequencing    pp721 - 734 Shuai Gao, Liying Yan, Rui Wang, Jingyun Li, Jun Yong et al. doi:10.1038/s41556-018-0105-4 Gao et al. provide a comprehensive single-cell transcriptomic resource of four organs from the human fetal gastrointestinal tract and adult large intestine.   Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. 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