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Nature Cell Biology contents: June 2018 Volume 20 Number 6

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TABLE OF CONTENTS

June 2018 Volume 20, Issue 6

Editorial
Research Highlights
News & Views
Comment
Letters
Articles
Resources
 
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Nature Index 2018 Japan

Some of Japan's smallest institutions are among the most efficient in the production of high quality scientific research, though the decline in Japan's high quality scientific research output continues. This supplement examines reform efforts in light of the country's aim to become a "super-smart" society.

Read the full supplement
 

Editorial

 

An update on organoid research    p633
doi:10.1038/s41556-018-0119-y

Research Highlights

 

A biobank for bladder cancer    p634
Christine Weber
doi:10.1038/s41556-018-0114-3

Modelling PDAC-niche adaption    p634
Christine Weber
doi:10.1038/s41556-018-0115-2

Organoids test drug response    p634
Christine Weber
doi:10.1038/s41556-018-0116-1

Gene corrections in sight    p634
Christine Weber
doi:10.1038/s41556-018-0117-0

Nature Cell Biology
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Innovations In: The Biggest Questions in Science

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News & Views

 

Protein quality and miRNA slicing get into phase    pp635 - 637
Tanja Mittag & Nicolas L. Fawzi
doi:10.1038/s41556-018-0113-4

Mammary lineage restriction in development    pp637 - 639
Philip Bland & Beatrice A. Howard
doi:10.1038/s41556-018-0111-6

A confetti trail of tumour evolution    pp639 - 641
Michalina Janiszewska & Kornelia Polyak
doi:10.1038/s41556-018-0110-7

Comment

 

Consent for governance in the ethical use of organoids    pp642 - 645
Sarah N. Boers & Annelien L. Bredenoord
doi:10.1038/s41556-018-0112-5

Letters

 

Regulation of cell cycle progression by cell–cell and cell–matrix forces    pp646 - 654
Marina Uroz, Sabrina Wistorf, Xavier Serra-Picamal, Vito Conte, Marta Sales-Pardo et al.
doi:10.1038/s41556-018-0107-2

Monitoring growing epithelial cells through the cell cycle, Uroz et al. find that cell–cell tension and cell–matrix traction forces differ across the cell cycle and affect cell cycle duration, the G1–S transition and mitotic rounding.

 

Articles

 

A PAX5–OCT4–PRDM1 developmental switch specifies human primordial germ cells    pp655 - 665
Fang Fang, Benjamin Angulo, Ninuo Xia, Meena Sukhwani, Zhengyuan Wang et al.
doi:10.1038/s41556-018-0094-3

Fang et al. identify a PAX5–OCT4–PRDM1 transcriptional network that acts as a developmental switch in the transition from human pluripotent stem cells to the primordial germ cell lineage.

 

Early lineage segregation of multipotent embryonic mammary gland progenitors    pp666 - 676
Aline Wuidart, Alejandro Sifrim, Marco Fioramonti, Shigeru Matsumura, Audrey Brisebarre et al.
doi:10.1038/s41556-018-0095-2

Wuidart et al. show that the mammary gland develops from embryonic multipotent progenitors that switch from multipotency to unipotency and express a unique gene signature. ΔNp63 promotes their basal fate and also reprograms adult luminal cells.

 

Clonal analysis of Notch1-expressing cells reveals the existence of unipotent stem cells that retain long-term plasticity in the embryonic mammary gland    pp677 - 687
Anna M. Lilja, Veronica Rodilla, Mathilde Huyghe, Edouard Hannezo, Camille Landragin et al.
doi:10.1038/s41556-018-0108-1

Lilja et al. report that multipotent mouse embryonic mammary cells become lineage restricted as early as embryonic day 12.5 during development in a potency switch regulated by Notch1 signalling.

 

Spectrin is a mechanoresponsive protein shaping fusogenic synapse architecture during myoblast fusion    pp688 - 698
Rui Duan, Ji Hoon Kim, Khurts Shilagardi, Eric S. Schiffhauer, Donghoon M. Lee et al.
doi:10.1038/s41556-018-0106-3

Duan et al. find that the membrane skeleton protein spectrin is required for myoblast fusion in Drosophila, accumulating in a mechanosensitive manner in the receiving partner during cell–cell fusion to modulate adhesion and protrusion events.

 

Multicolour lineage tracing reveals clonal dynamics of squamous carcinoma evolution from initiation to metastasis    pp699 - 709

doi:10.1038/s41556-018-0109-0

Reeves et al. use a multistage skin carcinogenesis mouse model and multicoloured lineage tracing to analyse the different patterns of clonal evolution and behaviour seen in progressing and non-progressing papillomas.

 

Resources

 

Single-cell analysis identifies a CD33+ subset of human cord blood cells with high regenerative potential    pp710 - 720
David J. H. F. Knapp, Colin A. Hammond, Tony Hui, Marijn T. J. van Loenhout, Fangwu Wang et al.
doi:10.1038/s41556-018-0104-5

Knapp et al. analyse the heterogeneous molecular profiles and functions of CD49f human cord blood haematopoietic stem cells and report that a subset with CD33 expression has improved regenerative activity.

 

Tracing the temporal-spatial transcriptome landscapes of the human fetal digestive tract using single-cell RNA-sequencing    pp721 - 734
Shuai Gao, Liying Yan, Rui Wang, Jingyun Li, Jun Yong et al.
doi:10.1038/s41556-018-0105-4

Gao et al. provide a comprehensive single-cell transcriptomic resource of four organs from the human fetal gastrointestinal tract and adult large intestine.

 

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